Begin your exploration into PAMPA analysis with our science, bundled software, and consumables package

PAMPA Explorer™ gives you access to pION's leading edge PAMPA technology, including the patented Double-Sink™ technology.  It includes a license for our PAMPA Explorer software and detailed instructions for running the PAMPA assay.

With the addition of the Gut-Box™, PAMPA assays can be done for 25% of the cost of a fully automated system.

PAMPA Explorer requires general laboratory equipment Molecular Devices SpectraMax® 190 or SpectraMax® Plus384 UV spectrophotometer.

We now offer monthly, yearly and perpetual licensing options depending on your budget.

PAMPA Explorer includes:

• PAMPA Sandwiches
• Explorer Command Software
• System Solution Concentrate
• Lipid Solution, sealed ampoule, N2 protected
• Consumables to process 10 PAMPA Sandwiches
• License to pION's patented technology

Double-Sink™
Our patented Double-Sink model uses pH gradient and an acceptor sink to mimic in vivo passive transport. This method correlates well with human absorption.

The Gut-Box™ is an important accessory for pION's PAMPA system. Designed with a built-in stirring mechanism, it is calibrated to specific speeds so that the PAMPA assay mimics the expected thickness of the aqueous boundary layer. The Gut-Box also provides controls for humidity, oxygen, and carbon dioxide.

The µSOL Explorer™ includes a license for the Command Software, and detailed instructions for performing the µSOL assay.  The µSOL Explorer requires general laboratory equipment, and a Molecular Devices SpectraMax® 190 or SpectraMax® Plus384 UV spectrophotometer.

pION offers monthly, yearly and perpetual licensing options, depending on your budget.

µSOL Explorer includes:

• Explorer Command Software
• Explorer Universal Buffer
• Consumables to process 10 sample plates
• Set of training compounds

In response to the increasing interest in characterizing intrinsic dissolution in early development where the active pharmaceutical ingredient is not available in large quantities, the µDISS ProfilerPLUS™ has been developed for small masses and volumes.

The µDISS Command software allows for easy method development. The µDISS ProfilerPLUS™ can be used to:

• Rank order intrinsic dissolution
• Detect polymorphic changes
• Follow stability profiles
• Determine equilibrium solubility

The Gemini Profiler™ is a semi-automated, state-of-the-art potentiometric analyzer for measuring pKa.  The instrument uses the potentiometric titration method developed by Alex Avdeef (pION's CEO & CSO).  The Gemini Profiler™ advantages include:

• Determnes pKa in the presence of some precipitation, since the instrument can correct for intrinsic solubility.
• The Gemini Profiler™ does not need to perform separate blank titrations.  The "ABC" electrode parameters can be determined in situ, at the same time that pKa values are determined.
• Any co-solvent can be used, including the water-miscible solvents polyethylene glycol, bile salts, and methylpyrrolidone.  It also can determine co-solvent pKa < 2 and pKa > 12.
• Determines log P and log D of ionized compounds.
• Determines intrinsic solubility and solubility as a function of pH (1-13, increments of 0.1)

Drug Discovery

With as little as 100 micrograms of sample, the Gemini Profiler™ delivers a complete solubility-pH profile. This allows you to make solubility an integral part of your optimization program at earlier stages of drug discovery, by allowing you to experimentally "calibrate" your high-throughput solubility prediction calculations. The result is earlier prediction of oral absorption.  Determination of pKa can be done separately or in conjunction with solubility measurement.

For the same effort as a manual single-pH solubility measurement, the Gemini Profiler™ determines the whole pH range, automatically. Not only aqueous solubilities, but also solubilities in DMSO, methanol and acetonitrile. Following guidelines consistent with the BioPharmaceutics Classification System, dose predicting is made easier. Solubilities less than 5 ng/mL to 50 mg/mL are possible.  You will not want to do another shake-flask solubility determination. pKas of sparingly soluble compounds are easily determined using a co-solvent extrapolation method.  In addition, compounds with multiple or overlapping pKas are not a problem for the Gemini Profiler™.